NFL Predictions, Betting Trends, Key Players & More The Kansas City Chiefs have been one of the biggest surprises in the National Football League through three weeks. Led by two-time AFC champion Patrick Mahomes' five touchdown passes and strong running game led by second-year back Kareem Hunt's strong playmaking abilities, they lead with nine sacks while also enjoying a solid running game that is led by Kareem Hunt himself.

Chiefs fans may soon face some difficulties: safety Derwin James was given a one-game suspension last week for breaking in-game rules designed to protect players' health and safety, though it will likely be overturned before this weekend's matchup with Los Angeles Chargers.

On offense, Chiefs guard/center Harrison Butker is expected to miss another week due to an injured foot, forcing them to utilize rookie third-round pick Matt Spaeth at center as a replacement. Such an adjustment would further disproportionally hamper an offense which has already struggled for consistency this season.

The Chargers, too, are dealing with injuries of their own. Starting quarterback Justin Herbert suffered an ankle sprain during Sunday's loss against Pittsburgh and is no longer at full strength; consequently, backups Taylor Heinicke or Easton Stick could find themselves taking on more of his workload in his absence.

Both teams' defenses have done an admirable job this season, while their offenses may take a greater hit due to a number of starters getting rest this week. Thus it may be difficult to accurately predict whether an incomplete Chiefs team can cover a 3 1/2-point spread against a lowly Chargers squad on the road.

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